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Investigating Deep Brain Stimulation of the Pedunculopontine Nucleus for the Treatment of Alzheimer’s Disease

What is this Study about?

This study explores Deep Brain Stimulation (DBS) as a potential treatment for mild Alzheimer’s disease (AD). In this study, the mild electrical stimulation is delivered to a part of the brain called the Pedunculopontine Nucleus (PPN), which helps regulate cognitive and sleep-related brain rhythms. The trial will recruit a small group of participants to evaluate the safety, feasibility, and preliminary efficacy of DBS-PPN in treating AD. The goal of this study is to see if targeting this part of the brain with DBS can help people living with mild AD improve their memory, thinking skills, and sleep quality.

What Will Happen in This Study?

This DBS-implantation procedure involves a 2–3-hour surgery under general anesthesia. A small wire will be implanted in the brain, and the DBS device (similar to a pacemaker) will be implanted under the skin by making a small incision. Over a 12-month period, participants will attend follow-up visits every 3 months, which include brain studies (EEG and MEG), cognitive assessments, and caregiver questionnaires. At the end of the study, participants have the option to remove the device or continue the intervention under the care of the study doctors.

Who is Eligible to Participate in this Study?

Are 60 years or older
-Have a diagnosis of mild Alzheimer's Disease
-Are fluent in English
-Have a personal caregiver willing to join the study

Get in Touch About this Study

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Observational Study

Target Population

Caregivers, Person living with Alzheimer’s disease

Target Age Group(s)

41-65

Study Location

In-Person

Toronto Western Hospital, Toronto

Ontario

Study Contact

Sophie Veri
Clinical Research Coordinator
Toronto Western Hospital (UHN)

Recruitment Start Date

May 30, 2025

Recruitment End Date

May 30, 2028
  • Learn more about observational studies
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