Eligibility Criteria

• You are 18 years of age or older.
• You have an interest in frailty and dementia.
• This includes researchers, healthcare professionals, policy and decision-makers, older adults, care partners, advocates, and others with relevant interest or experience.
• You speak English.

Eligibility Criteria

You are eligible to participate if you:

Are 50 years of age or older

Either have healthy cognition or are experiencing noticeable memory or thinking changes (Subjective Cognitive Decline), or have a clinical diagnosis of Mild Cognitive Impairment (MCI) or dementia.

Have access to a computer, laptop, or tablet with a reliable internet connection.

Are able to provide informed consent, or have a legally authorized Substitute Decision Maker (SDM) who can provide consent on your behalf.

Have adequate vision and motor skills to view a screen and tap or click to respond to prompts (such as a choice reaction time task), using glasses or standard aids if necessary.

Are able to read and communicate in English.

Do not have comorbid psychiatric conditions that interfere with cognitive function Do not have a history of brain injury or neurodevelopmental disorders

Eligibility Criteria

• Are between 55-85 years of age

• Have one or more of these risk factors for Alzheimer's disease (AD):

- A parent or sibling with AD *and* concerns about your own memory

- Two copies of the APOE e4 gene

- A positive AD biomarker result

• Get normal scores on tests of thinking and memory (will be done as part of the study)

• Are able to undergo brain MRI scans

• Are fluent in English

• Are able to attend study visits at Toronto Western Hospital

• Show increased brain signaling during the screening fMRI scan (Note: We anticipate that most people who sign up for the study will NOT show the increased brain activity levels required to qualify for the study treatment)

Eligibility Criteria

Male or female participants aged 55 to 90 years of age
Must have a study partner
Presence of psychotic symptoms for at least 2 months before Screening.

Eligibility Criteria

Male or female participants aged 50 years of age to 90.
Must have a study partner
Participant- and/or Informant-reported history of cognitive decline with gradual onset and progression over the last 1 year before screening

Eligibility Criteria

Male or female participants aged 55 years of age to 90.
Must have a study partner
History of agitation due to AD.

Eligibility Criteria

1.) Diagnosed with Dementia and/or memory loss by a clinician

2.) Exhibit adequate oral communication skills and cognitive function

3.) Walk or stand with or without personnel or assistive devices

4.) Individuals must be greater than or equal to 50 years of age

Eligibility Criteria

You are eligible to participate if you:

• Are an older adult living with dementia who attends or does not attend a day program

• You are a family/friend caregiver of someone living with dementia who attends or does not attend a day program

• Live in one of the participating regions (Ontario, Winnipeg MB, Calgary AB, or Interior BC)

• Are able to take part in a conversation or complete surveys, with support if needed

Eligibility Criteria

You are eligible to participate if you:

Are 18 years of age or older

Are living with mild cognitive impairment (MCI) or dementia, or are a care partner of someone with MCI or dementia

Are able to use a smartphone or tablet with the GuardIO app

Are willing to participate in the study activities, including using the app, completing questionnaires, and attending an optional focus group

Can understand and communicate in English (or another supported language, if applicable)