Our study titled "Investigating the Role of Quantitative Susceptibility Mapping and Oxygen Extraction Fraction as Advanced Neuroimaging Biomarkers in Alzheimer's Disease" aims to develop non-invasive diagnostic biomarkers for Alzheimer's Disease (AD). We focus on evaluating the potential of QSM and OEF to differentiate between AD, Mild Cognitive Impairment (MCI), and Cognitively Unimpaired populations and to predict amyloid and tau pathology, using a Systems Biology approach. Leveraging the McGill University's TRIAD cohort, the study utilizes advanced imaging and machine learning to predict amyloid and tau presence, which could transform AD diagnostics and treatment. Methodologically, it involves preprocessing neuroimaging data and employing machine learning classifiers to analyze these features. The anticipated outcomes include validating QSM and OEF as non-invasive biomarkers for AD, establishing their correlation with amyloid and tau proteins, and developing predictive models for clinical decision-making, potentially resulting in significant advancements in AD diagnostics.
Are a member of the TRIAD cohort at McGill University, falling within one of the following categories: young control, cognitively unimpaired, mild cognitive impairment, or Alzheimer's Disease.
Are willing and able to undergo advanced neuroimaging techniques including MRI and PET without contraindications.
Have not had any significant neurological conditions (other than AD for the AD group) that might interfere with the results of the study.
Have no metal implants, devices, or other conditions that may contraindicate or distort MRI imaging.
Are not currently participating in other clinical trials or studies that involve interventions which might interfere with the results of this study.
Are able and willing to provide informed consent for participation in the study or have a legally authorized representative who can do so.
Do not have a history of substance abuse or other conditions that might confound the imaging and cognitive data.
Have not undergone any significant head trauma or surgery in the past 6 months.
Are not pregnant or planning to become pregnant during the duration of the study.
Are willing to comply with all study-related procedures, imaging sessions, and follow-up evaluations.
Ability to speak English and French
The purpose of this study is to assess whether a virtually-delivered healthy lifestyle intervention (over Zoom) is feasible for individuals who feel that their memory or thinking is declining.
-Are between the age of 65-85
-Are concerned about your memory and other thinking abilities
-Have access to internet at home
-Are a resident of Saskatchewan, Manitoba, Ontario, or Quebec
The aging of the Canadian population and the lack of care personnel increase the number and responsibilities of family caregivers with the elderly. By adopting the first policy recognizing caregivers in Quebec in April 2021, the Quebec government is committed to better supporting caregivers in order to lighten their burden. The time is more appropriate than ever to highlight the reality of informal support for seniors from ethnocultural communities in the context of immigration. More specifically, our study aims to identify the trajectories of caregiving within the Maghreb community. Collecting data from key people would allow us to have an external perspective on the issue studied and would enrich our understanding of the realities and experiences of caregivers in the context of immigration (case study: the North African community), of their network of support as well as the potential impact of migration trajectories and Maghrebian culture on his practice of close care.
- Be a person over 18 years old.
- Identify yourself as a person of North African origin, i.e. from Morocco, Algeria, Tunisia, Libya and Egypt.
- Be a permanent resident, Canadian citizen by naturalization. Or be born in Canada and have at least one parent born in the Maghreb (Morocco, Algeria, Tunisia, Libya, Egypt).
- Reside in Quebec
- Support an elderly relative who also lives in Quebec or have supported an elderly relative during the last five years.
We are interested in visuospatial abilities in patients with possible or probable Alzheimer’s disease at an early stage. The experiment will be carried out online on a computer in your home, over three years
We are conducting a study to better understand caregiving experiences in order to validate a new tool to help screen for caregiver burden related to swallowing difficulties. The information you provide will be combined with information from other participants to help us better understand caregiving experiences, especially related to swallowing difficulties.
The aim is to better understand the cognitive strengths and difficulties related to visuospatial skills among people with Mild Cognitive Impairment and/or early Alzheimer's Disease through cognitive tasks.