Aim – To determine how continued education and adult learning classes affects brain health and cognitive processing in older adults.
How the information gathered will be used – The results of this study may inform how structural and functional changes lead to the cognitive decline some individuals experience with age and the effect of learning and adult education on cognitive performance in older adults experiencing mild cognitive impairment.
You are eligible to participate if you are:
(1) Aged 60-80 years old,
(2) Live in your own home,
(3) Feel your memory ability has declined in the last 5 years, and
(4) Read, write and speak English.
This Phase 2 study aims to study to evaluate the efficacy and safety of study treatment in paticipants with Mild Cognitive Impairment Due to Alzheimer's Disease or Mild Alzheimer's Disease Dementia
Age 50 - 80
Mild cognitive impairment (MCI) or mild dementia due to Alzheimer's disease
The primary objective of this study is to verify the clinical benefit of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score as compared with placebo in participants with early Alzheimer's disease.
Age 60 - 85
Must have a study partner
The purpose of this study is to see how signals from the body, and awareness of those signals, influence cognition in healthy aging and amnestic mild cognitive impairment. The data used from this study will be used for scientific publications and conference presentations. Participants will also be asked if they are willing to have their deidentified data shared for the benefit of open science.
You are eligible to participate if you are between the ages of 60-85, are free from major medical, neurological, or psychiatric conditions affecting cognition or cardiac health, are fluent in English, and have normal or corrected-to-normal vision.
The aim of this research is to investigate the short-term and long-term effects of music-assisted learning on memory function and verbal learning in participants with mild memory loss.
You may be able to participate in this study if:
• You are 60-85 years of age
• You have mild memory loss
• You have a reliable study partner (spouse, child, close friend or family member)
• You are right-handed
• You have travel ability to The University of Toronto St. George Campus
You will not be able to participate in this study if:
• You have a clinical diagnosis of dementia
• Your English or French is not sufficient to undergo clinical and neuropsychological assessments (tests of memory and thinking)
• You have hearing impairments that would prevent you from participating
• You have a current unstable psychiatric illness
• You have a history of head trauma, symptomatic stroke, or moderate to severe traumatic brain injury
• You have a current or past learning or attentional disorder
• You have a current or past experience with substance abuse
• You have participated in any formal music training in the past 10 years
Increasing evidence shows that listening to music from childhood and early adulthood can help recall meaningful events from the past. Importantly, people with dementia have shown to benefit from listening to personally meaningful music, suggesting that musical memory remains preserved. However, the underlying mechanisms by which music improves memory remains unclear.
My research addresses the impact of an autobiographically salient music listening program on memory and brain activity in mild cognitive impairment. Understanding how brainwave activity in this population may differ, will help elucidate mechanisms of music listening that lead to cognitive improvements, ultimately providing insight into musical memory preservation and how it can be leveraged.
Participants will undergo cognitive testing and measure brainwave activity via EEG, a non-invasive neuroimaging method. Participants will be provided an online link (or CD if they do not have wifi) to access their personalized music playlist and will be asked to listen for two weeks at home (20 mins/day, minimum 5 days/wk). Repeated cognitive and EEG assessment will help determine changes in brain function.
- are 60 years of age and over
- have received a diagnosis of mild cognitive impairment; or are generally healthy
- are English speaking
- have a minimum of high school education
- have adequate hearing and vision
- can identify 15 English vocal/lyrical songs that are associated to your personal memories
- can commit to listening to your personal playlist (20 mins) at-home for 2 weeks (minimum 5 days/week)
The aim of our study is to better understand whether certain lifestyle factors (such as physical activity and hearing) are related to early changes in memory and thinking abilities in older adults. We are especially interested in enrolling individuals who are South Asian or East Asian, because little research has focused on brain health in Canadians of diverse racial/ethnic backgrounds.
By participating, you will help us better understand how lifestyle factors are related to memory and thinking changes in adults from diverse communities. We hope that this will lead to improved prevention and early intervention strategies for dementia.
You are eligible to participate if you…
- Are 55-85 years old
- Have no major medical or psychiatric diagnoses
- Are comfortable speaking and reading English
- Are able to undergo an MRI scan
Eligibility is dependent on an additional conversation with the study team.
VRx@Home is a 5-week virtual reality at-home intervention with the goal to explore whether virtual reality experiences can enhance communication between persons living with dementia and their care partners. We also aim to explore how a head-mounted VR system, which delivers a fully immersive experience compares to a Tablet-based technology.
The study is aiming to assess whether nutritional intervention with personalized, preselected prebiotics can affect cognitive function in those with Alzheimer’s disease. This study is placebo-controlled, and participants will be randomized to either the placebo or prebiotic.