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  • Observational Study
    Online

    Examining Social Support among Black Dementia Caregivers in the Greater Toronto Area

    What is this Study about?

    This study examines how Black family caregivers in the Greater Toronto Area experience and access social support while caring for a relative living with dementia. Using Straussian Grounded Theory informed by Critical Theory and Intersectionality, the research explores how factors such as race, culture, gender, and community shape caregiving experiences and support-seeking behaviours. Findings will be used to develop theory grounded in the lived experiences of Black caregivers, and to inform more culturally responsive dementia care policies, services, and supports across Canada. This study has been approved by the York University Research Ethics Board (Protocol 130, April 2026).

    Eligibility Criteria

    You are eligible to participate if you:

    • self-identify as Black (for example, African, Caribbean, Black Canadian, Afro-Latin, or another Black identity)
    • are 18 years of age or older
    • live in the Greater Toronto Area
    • provide unpaid care to a family member living with dementia
    • can speak and understand English well enough to take part in an interview

    Recruitment End Date

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  • Observational Study
    Online

    Supporting safe and healthy sexual expression for people living with dementia in long-term care settings

    What is this Study about?

    We developed a resource to support substitute decision-makers as they work through issues related to the sexual expression of individuals living with dementia in long-term care homes. The purpose of this pilot is to evaluate and assess how the content and format of the resource is received by a sample of substitute decision-makers and longterm care staff members. Through online surveys, we will be seeking feedback related to accessibility, potential usefulness in practice, effectiveness in increasing awareness and preparedness to address issues related to sexual expression.

    Eligibility Criteria

    - are a substitute decision-maker of a person living with dementia in residential long-term care in Alberta or Ontario OR someone currently working with people living with dementia in residential long-term care in Alberta or Ontario;

    - are a person who is 18 years of age or older;

    - are a person able to read and write in English

    Recruitment End Date

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  • Observational Study
    In-Person

    Levetiracetam for Persons at Risk for Alzheimer's Disease (ALEVIATE-2)

    What is this Study about?

    The goal of this study is to investigate whether very small doses of a drug called levetiracetam (LEV) may reduce abnormal brain signaling in the brain in individuals who are at an increased risk for developing Alzheimer's Disease. Only participants who show the abnormal brain signaling on a functional MRI (fMRI) scan of the brain will be enrolled in the study. Enrolled participants will receive 4 weeks of treatment with LEV and 4 weeks of treatment with placebo (a sugar pill). The study involves cognitive testing, genetic testing, bloodwork, ECGs, questionnaires and several brain imaging scans.

    Eligibility Criteria

    • Are between 55-85 years of age

    • Have a parent or sibling with Alzheimer’s disease or with dementia that may be due to Alzheimer’s disease (even if not diagnosed as such)

    • Feel your memory is getting worse

    • Get normal scores on tests of thinking and memory (will be done as part of the study)

    • Are able to undergo brain MRI scans

    • Have a study partner (friend or family member) willing to answer questionnaires about you

    • Show increased brain signaling during the screening fMRI scan (Note: We anticipate that most people who sign up for the study will NOT show the increased brain activity levels required to qualify for the study treatment)

    Recruitment End Date

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  • Observational Study
    In-Person

    Comprendre la perception de la parole dans le bruit chez les personnes âgées.

    What is this Study about?

    Votre mémoire vous inquiète? Le laboratoire des neurosciences de la parole et de l'audition de l'Université Laval vous invite à participer à un projet de recherche visant à comprendre la relation entre la cognition, l'audition et ladifficulté de perception de la parole dans le bruit au cours du vieillissement. La participation implique un maximum de 3 visites au Centre de recherche CERVO. La compensation totale pour l’étude est de 150$. Un résumé écrit devotre fonctionnement cognitif vous sera remis à la fin de votre participation

    Eligibility Criteria

    Les critères de base pour participer sont :

    - Être âgé de 50 ans et +

    - Avoir le français québécois comme langue principale

    - Être droitier

    - Avoir des inquiétudes concernant le fonctionnement de sa mémoir

    Recruitment End Date

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  • Observational Study
    Online

    Nature-based Virtual Reality Intervention for Depression in Alzheimer’s Disease (VRN-AD)

    What is this Study about?

    This study looks at how an at-home nature-based virtual reality (VR) program may help people living with Alzheimer’s Disease manage behavioural and psychological symptoms of dementia (BPSD), such as depression. Caregivers and/or study partners will have the option of taking part in the study and providing feedback regarding the VR intervention. This project will explore how virtual reality can be used as a non-pharmacological approach to prolong aging in place for individuals with BPSD, as BPSD contributes to rates of institutionalization.

    Eligibility Criteria

    • Are 50 years or older
    • Have been diagnosed with mild to early-moderate Alzheimer's disease (including mixed dementia)
    • Are medically stable and able to take part safely
    • Experience mild to moderate depressive symptoms
    • Feel comfortable using basic technology, such as a tablet or headset
    • Have access to Wi-Fi and a smart device (such as a phone or tablet) for online sessions and study apps
    • Have someone available to be present during all study sessions

    Recruitment End Date

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  • Clinical Trial
    In-Person

    A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Hallucinations and Delusions Associated with Alzheimer's Disease Psychosis

    What is this Study about?

    ML-007C-MA-221 is a Phase 2, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of ML-007C-MA in male and female participants aged 55 to 90 years with hallucinations and delusions associated with Alzheimer's Disease Psychosis (ADP).

    The primary objective is to evaluate the efficacy of ML-007C-MA compared with placebo for the treatment of hallucinations and delusions associated with ADP as measured by the Neuropsychiatric Inventory-Clinician (NPI-C): Hallucinations and Delusions (H+D) score.

    Eligibility Criteria

    Male or female participants aged 55 to 90 years of age
    Must have a study partner
    Presence of psychotic symptoms for at least 2 months before Screening.

    Recruitment End Date

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  • Clinical Trial
    In-Person

    A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Intrathecally Administered ALN-APP in Patients With Cerebral Amyloid Angiopathy (CAA)

    What is this Study about?

    The purpose of the study is to evaluate the effect of ALN-APP on measures of CAA disease progression and to characterize the safety, tolerability, and pharmacodynamics (PD) of ALN-APP in adult patients with sporadic CAA (sCAA) and Dutch-type CAA (D-CAA). The study will be conducted over 2 periods: a 24-month double-blind treatment period and an optional 18-month open-label extension (OLE) period. The estimated duration of study participation, inclusive of screening, treatment, and additional safety follow-up, is up to 50 months.

    Eligibility Criteria

    Male or female participants aged 50 years of age
    Has a history of previous clinical intracerebral hemorrhage.
    Has probable CAA.

    Recruitment End Date

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  • Clinical Trial
    In-Person

    Master Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies as Assessed by Biomarker Status and Cognition

    What is this Study about?

    This study is a pre-screening process used to assess participants' potential eligibility for Roche interventional Alzheimer's disease studies.

    Eligibility Criteria

    Male or female participants aged 50 years of age to 90.
    Report of objective or subjective memory concerns (by the participant and/or their informant) within the last year with or without a previous clinical diagnosis of MCI or dementia due to AD.

    Recruitment End Date

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  • Clinical Trial
    In-Person

    A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Efficacy and Safety Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease (MCI to Mild Dementia Due to AD)

    What is this Study about?

    The purpose of this study is to assess the efficacy and safety of trontinemab in participants with early symptomatic Alzheimer's disease (AD) (mild cognitive impairment [MCI] to mild dementia due to AD).

    Eligibility Criteria

    Male or female participants aged 50 years of age to 90.
    Must have a study partner
    Participant- and/or Informant-reported history of cognitive decline with gradual onset and progression over the last 1 year before screening

    Recruitment End Date

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