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  • Observational Study
    Online & In-Person

    What is this Study about?

    Seeking individuals with mild, early-stage dementia ages 65+ to explore how they access daily information like weather forecasts and newspapers. The study aims to improve information accessibility for the dementia community. Participation involves a 60-90 minute session (in-person or via Zoom with caregiver) observing information access behaviors. Findings will guide strategies for making information more comprehensible and accessible. Participants will receive $50 for their time. This study is approved by York University’s ethics committee (#2024-176). For details, contact Dr. Somang Nam at [email protected].

    Eligibility Criteria

    Individuals diagnosed with mild, early-stage dementia.
    Caregivers may participate to support individuals meeting the above criteria.
    Participants must be able to engage in a 60-90 minute session, either in person or via Zoom.

    Recruitment End Date

  • Observational Study
    Online & In-Person

    What is this Study about?

    We are interested in how the brain changes in aging and with dementia. With this study, we will investigate how the brain senses and interprets sights and sounds. We are particularly interested in how listening to music, especially familiar music, evokes emotions and activates vivid memories. Learning how the brain processes music will help us understand why music therapy is such an effective tool for those with Alzheimer’s. We also aim to understand how the brain combines sights and sounds. This is an important part of how we navigate complex everyday situations, such as walking down a busy street. Alzheimer’s disease interferes with the brain’s ability to combine information from different senses, which could cause challenges in daily living.

    Eligibility Criteria

    You are eligible to participate in this study if you are:

    • A healthy young adult aged 18-35, a healthy older adult aged 65 and up, or an older adult with mild/early-stage dementia as diagnosed by your doctor
    • Able to provide written, informed consent to participate
    • Have normal or corrected-to-normal hearing in both ears and vision in both eyes
    • You must have no history of cerebro-vascular injury or accident (such as a stroke)
    • For adults without dementia, you must have no known neurological conditions and must not be taking any neuroactive drugs

    You will not be eligible to participate in the study if you:

    • Have metallic objects that cannot be removed for the MEG recording (such as permanent piercings and medical implants that are made from magnetic metals)
    • Are pregnant
    • Feel you cannot perform the audio-visual and/or music listening tasks

    Recruitment End Date

  • Clinical Trial
    Online

    What is this Study about?

    The Communication Bridge 3 Study is focused on helping adults with mild to moderate Primary Progressive Aphasia (PPA), a condition that affects language abilities due to neurodegenerative diseases. The study aims to improve functional communication and life participation by providing structured language and communication support remotely through video conferencing.

    Participants work with speech-language pathologists to practice communication techniques and learn strategies to address daily communication challenges. The study involves a series of therapy sessions, assessments, and follow-up evaluations to measure changes in communication and participation over time. By tracking participants' progress, the study hopes to identify effective approaches for enhancing quality of life for those living with PPA and their care partners.

    Eligibility Criteria

    You are eligible to participate if you speak English as a primary language, a confirmed diagnosis of PPA in mild to moderate impairment stage, a communication partner that is willing to participate, and sufficient internet connection.

    Recruitment End Date

  • Clinical Trial
    Ontario

    What is this Study about?

    McMaster University, in partnership with Ressam Gardens Memory Care Community, is conducting a study on the effects of brain stimulation in individuals aged 50 and older with dementia or memory loss. The research focuses on using repetitive transcranial magnetic stimulation (rTMS), a non-invasive technique that delivers magnetic pulses to the brain, to enhance cognitive function and balance. The goal is to extend the positive effects of brain stimulation in improving cognition and balance in individuals with dementia.

    Eligibility Criteria

    You are eligible to participate if you…

    1.) Diagnosed with Dementia and/or memory loss by a clinician

    2.) Exhibit adequate oral communication skills and cognitive function sufficient to obtain a score ranging between 10-27 on the Mini-Mental State Exam

    3.) Walk or stand with or without personnel or assistive devices

    4.) Individuals must be greater than or equal to 50 years of age

    Recruitment End Date

  • Observational Study
    In-Person

    What is this Study about?

    This study will uncover how bilingualism supports healthy cognitive aging by examining the influence of different language experiences on the timing and location of brain network activity. We will examine the timing of brain activity using electroencephalography (EEG; i.e., recordings of electrical brain activity) and the location of brain activity using magnetic resonance imaging (MRI; i.e., images of activity in different parts of the brain). Different language experience factors will additionally be explored. By measuring multiple factors (e.g., the age of second language learning, language proficiency) the effect(s) of different language experiences on the brain and cognition will become clearer.

    Eligibility Criteria

    You are eligible to participate if you:

    - are a French-English bilingual over the age of 65

    - have mild cognitive impairment

    - have Alzheimer's disease

    - are a healthy older adult (i.e., have no cognitive conditions)

     

    Please note that you do not need to be completely fluent in both English and French, just to have some familiarity, experience or training with both languages to be eligible to participate.

    Thank you for your consideration!

    Recruitment End Date

  • Observational Study
    Online

    What is this Study about?

    CAN-PROTECT is a Canada-wide online study recruiting participants and caregivers of persons with dementia to explore how lifestyle, background, and caretaking factors affect our health, quality of life, cognition, behaviour, and function as we age. CAN-PROTECT data will be analyzed and jointly published by the University of Calgary in partnership with the University of Exeter.

    Eligibility Criteria

    - Age 18 years or older

    - Reside in Canada

    - Have access to a computer/touchscreen device

    - Can provide informed consent

    - Do not have a diagnosis of dementia

    - Additionally, we are enrolling participants who have previously or currently care for persons with dementia for caregiver-specific assessments

    - Ability to speak English

    Recruitment End Date

  • Clinical Trial
    In-Person

    What is this Study about?

    It is expected that the information collected during this study will be used in analyses and will be published/presented to the scientific community at meetings and in journals. This information may also be used as part of a submission to regulatory authorities around the world to support the approval of the study intervention for agitation in AD.

    Eligibility Criteria

    You are eligible to participate if you meet the following criteria:

    • Age ≥ 55; females must be post-menopausal

    • DSM-5 criteria for Major Neurocognitive Disorder due to AD; multiple etiologies (AD and vascular)

    • sMMSE ≤ 24

    • Clinically significant agitation based on IPA definition

    • Stable cognition-enhancing medication for at least 3 months prior to study enrolment

    • Availability of a caregiver to accompany participant to study visits and to participate in the study

    • Ability to speak English

    Recruitment End Date

  • Clinical Trial
    Online & In-Person

    What is this Study about?

    To examine the effects of a stress management program on well-being, stress, and cognition in family caregivers of someone with dementia or a related neurodegenerative disorder. We will be recruiting participants from 2023 - 2027.

    Eligibility Criteria

    - are a primary family caregiver of a person with dementia or a related neurodegenerative disorder.

    - have access to a computer with high-speed internet; and feel comfortable using email and Zoom (a secure online meeting platform).

    - have a video camera on your device. To ensure safety of participants during the program sessions, it is important that participants turn on their video camera. Keeping the video camera on is also important to build trust within the group sessions and when interacting with the researchers.

    - are willing to be randomised to one of 3 groups, even if it is not your preferred group.

    - are able to commit to a synchronous 8-week online group-based program (described below) and complete daily prescribed daily home practices.

    - are able to commit to three assessment sessions: one baseline assessment, one post-program assessment, one 12-month follow-up assessment.

    - agree to audio recording of interview sessions and portions of the assessment that require accurate verbal data collection.

    - are able to provide blood samples, potentially after a 12-hour fast.

    - are able to travel to a LifeLabs clinic for biomarker collection.

    - agree to refrain from participating in new studies or programs during the 8-week study session.

    - meet the screening criteria during the pre-screening interview.

    - ability to speak English.

    Recruitment End Date

  • Observational Study
    In-Person

    What is this Study about?

    Our study titled "Investigating the Role of Quantitative Susceptibility Mapping and Oxygen Extraction Fraction as Advanced Neuroimaging Biomarkers in Alzheimer's Disease" aims to develop non-invasive diagnostic biomarkers for Alzheimer's Disease (AD). We focus on evaluating the potential of QSM and OEF to differentiate between AD, Mild Cognitive Impairment (MCI), and Cognitively Unimpaired populations and to predict amyloid and tau pathology, using a Systems Biology approach. Leveraging the McGill University's TRIAD cohort, the study utilizes advanced imaging and machine learning to predict amyloid and tau presence, which could transform AD diagnostics and treatment. Methodologically, it involves preprocessing neuroimaging data and employing machine learning classifiers to analyze these features. The anticipated outcomes include validating QSM and OEF as non-invasive biomarkers for AD, establishing their correlation with amyloid and tau proteins, and developing predictive models for clinical decision-making, potentially resulting in significant advancements in AD diagnostics.

    Eligibility Criteria

    Are a member of the TRIAD cohort at McGill University, falling within one of the following categories: young control, cognitively unimpaired, mild cognitive impairment, or Alzheimer's Disease.

    Are willing and able to undergo advanced neuroimaging techniques including MRI and PET without contraindications.

    Have not had any significant neurological conditions (other than AD for the AD group) that might interfere with the results of the study.

    Have no metal implants, devices, or other conditions that may contraindicate or distort MRI imaging.

    Are not currently participating in other clinical trials or studies that involve interventions which might interfere with the results of this study.

    Are able and willing to provide informed consent for participation in the study or have a legally authorized representative who can do so.

    Do not have a history of substance abuse or other conditions that might confound the imaging and cognitive data.

    Have not undergone any significant head trauma or surgery in the past 6 months.

    Are not pregnant or planning to become pregnant during the duration of the study.

    Are willing to comply with all study-related procedures, imaging sessions, and follow-up evaluations.

    Ability to speak English and French

    Recruitment End Date