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  • Observational Study
    In person

    What is this Study about?

    This study explores Deep Brain Stimulation (DBS) as a potential treatment for mild Alzheimer’s disease (AD). In this study, the mild electrical stimulation is delivered to a part of the brain called the Pedunculopontine Nucleus (PPN), which helps regulate cognitive and sleep-related brain rhythms. The trial will recruit a small group of participants to evaluate the safety, feasibility, and preliminary efficacy of DBS-PPN in treating AD. The goal of this study is to see if targeting this part of the brain with DBS can help people living with mild AD improve their memory, thinking skills, and sleep quality.

    Eligibility Criteria

    Are 60 years or older
    -Have a diagnosis of mild Alzheimer's Disease
    -Are fluent in English
    -Have a personal caregiver willing to join the study

    Recruitment End Date

  • Observational Study
    In person and online

    What is this Study about?

    Help Us Improve Support for Alzheimer’s Caregivers

    We are inviting caregivers, healthcare providers, community organizations, and Alzheimer’s societies to take part in a research study focused on improving support for people caring for individuals with Alzheimer’s disease.

    What is this study about?
    We know that caregiving is a journey that changes over time, but many caregivers don’t have access to tools or services that meet their evolving needs. This study aims to change that by bringing together caregivers and professionals to co-create practical resources and tools that support caregivers through each stage of the disease.

    What will participation involve?
    Participation will mostly take place virtually and includes online surveys, focus groups, and/or one-on-one interviews through secure platforms like Zoom or Microsoft Teams. You’ll be asked about your experiences with caregiving and the services available to you. Later, we’ll host in-person co-design sessions to work together on building useful tools and guidance for caregivers.

    Why join?
    By participating, you’ll have the chance to reflect on your experience, identify gaps in current services, and help shape resources that better support caregivers like you. You may also learn about services you didn’t know existed. Your input will directly inform more responsive and timely support for caregivers and people living with Alzheimer’s.

    Eligibility Criteria

    1. Caregivers who are providing care to a loved one with Alzheimer’s disease or related dementias, particularly those in the following caregiving stages: o Monitoring initial symptoms o Navigating diagnosis o Assisting with instrumental and basic activities of daily living o Preparing for the future

    o Monitoring initial symptoms

    o Navigating diagnosis

    o Assisting with instrumental and basic activities of daily living

    o Preparing for the future

    2. Service providers (e.g., healthcare professionals, social workers, home care aides) who deliver Alzheimer’s related care or services to individuals in these caregiving stages

    Recruitment End Date

  • Observational Study
    In-Person

    What is this Study about?

    Thinking skills (also known as cognitive functions), change from younger to older adulthood. In this study we are investigating how these shifting architectures of cognition and brain function relate to one another, and how these brain and cognitive changes impact decision-making in younger and older adults.

    You may qualify to participate if you are: 1) 60 years of age or older, 2) right-handed, 3) in good health, 4) and have normal or corrected-to-normal vision. Participation will involve completing cognitive tasks, questionnaires, and non-invasive brain measurements using MRI. If you are interested in participating in this study, please contact [email protected]

    Eligibility Criteria

    You are eligible to participate if you:

    - Are aged 60 years or older

    - Are right-handed

    - Are cognitively healthy

    - Are able to come in-person to our site, located at the Montreal Neurological Institute

    - Have no metal in your body (e.g., pacemaker, metal plates, orthopedic devices, etc.)

    - Speak English or French

    Recruitment End Date

  • Observational Study
    In person and online

    What is this Study about?

    This research aims to explore the perspectives of older adults living with dementia, providing a nuanced understanding of their experiences and challenges. Second, it seeks to investigate the role of physical activities in their lives, examining how engagement in such activities influences their cognitive function and mental well-being. Finally, this research aims to inform interventions and policies that can support older adults in maintaining their cognitive health and overall well-being.


    The data will be used for the researcher’s master’s thesis, and for publishing peer-reviewed and non-peer reviewed articles, conference presentations, webinars, and presentations for professionals.

    Eligibility Criteria

    1.You are eligible to participate if you are a member of the Minds in Motion program.
    2.You are eligible to participate if you age 65 and above.
    3.You are eligible to participate if you are diagnosed with mild-to-moderate dementia.
    4.You are eligible to participate if you actively engaged in some form of physical activity in addition to minds in motion physical activities (e.g. swimming, nature walks, aerobics, chair exercises).
    5. You are eligible to participate if you can give informed consent.

    Recruitment End Date

  • Observational Study
    In person and online

    What is this Study about?

    This study aims to evaluate the acceptance and usability of the GuardIO Family Care app, a mobile application designed to support community safety for individuals living with dementia or mild cognitive impairment and their care partners. The study also aims to analyze mobility patterns collected from the app to explore how mobility data can contribute to the early detection of cognitive impairment. The findings will help improve app design, inform care strategies, and support early intervention efforts for individuals living with dementia or MCI.

    Eligibility Criteria

    You are eligible to participate if you:

    Are 18 years of age or older

    Are living with mild cognitive impairment (MCI) or dementia, or are a care partner of someone with MCI or dementia

    Are able to use a smartphone or tablet with the GuardIO app

    Are willing to participate in the study activities, including using the app, completing questionnaires, and attending an optional focus group

    Can understand and communicate in English (or another supported language, if applicable)

    Recruitment End Date

  • Observational Study
    In-Person and Online

    What is this Study about?

    This study is testing a digital reminder system for people living with dementia. The system sends alerts when daily routines change and collects feedback from caregivers. The goal is to improve the system’s design and usefulness. Results will help make reminder tools more supportive for people living with dementia and their caregivers.

    Eligibility Criteria

    You are eligible to participate if you are a person living with dementia and you:
    - Have a clinical diagnosis of mild to moderate dementia
    - Were diagnosed within the past 2 years
    - Speak and understand English
    - Are able to give informed consent
    - Have internet access at home
    - Are part of a caregiver-participant pair (dyad)

    You are eligible to participate if you are a caregiver and you:
    - Are an informal caregiver (family member or friend)
    - Provide at least 30 hours of care per week to a person living with dementia
    - Speak and understand English
    - Are able to give informed consent
    - Can participate in a home setup session and follow-up interview

    Recruitment End Date

  • Observational Study
    Online & In-Person

    What is this Study about?

    In collaboration with our South Asian community collaborators, our goal is to gain an in-depth understanding of new immigrant, multigenerational, South Asian family caregiving for a relative with dementia amidst COVID-19. The goal is to inform future family-centered, healthcare interventions aimed at supporting equity deserving families during times of crisis.

    To achieve our goal, we are starting to recruit family care partners living in a multigenerational home and caring for a relative with dementia from each of the four groups of South Asian families. We will be using a multiple case study to examine new immigrant, multigenerational caregiving for a relative with dementia from the perspective of four groups of South Asian families; 1) Pakistani, 2) Bangladeshi, 3) Indian, and 4) Sri Lankan. We will also be using secondary data sources, including genograms, ecoMaps, and key documents.

    We will be conducting interviews with a family care partners from each of the four groups. Following these interviews, we will hold four focus groups with a new purposeful sample of South Asian multigenerational care partners to understand if the findings from the interviews reflect their caregiving experiences thereby increasing the reliability of the study findings.

    Eligibility Criteria

    You are eligible if

    1. You are caring for a family member or relative with memory loss or dementia

    2. You are living in a multigenerational South Asian Family

    3. You Identify with any of these four South Asian Countries: India, Pakistan, Bangladesh and Sri Lanka

    4. You live in the Greater Toronto Area (GTA)

    Recruitment End Date

  • Clinical Trial
    Online

    What is this Study about?

    The Communication Bridge 3 Study is focused on helping adults with mild to moderate Primary Progressive Aphasia (PPA), a condition that affects language abilities due to neurodegenerative diseases. The study aims to improve functional communication and life participation by providing structured language and communication support remotely through video conferencing.

    Participants work with speech-language pathologists to practice communication techniques and learn strategies to address daily communication challenges. The study involves a series of therapy sessions, assessments, and follow-up evaluations to measure changes in communication and participation over time. By tracking participants' progress, the study hopes to identify effective approaches for enhancing quality of life for those living with PPA and their care partners.

    Eligibility Criteria

    You are eligible to participate if you speak English as a primary language, a confirmed diagnosis of PPA in mild to moderate impairment stage, a communication partner that is willing to participate, and sufficient internet connection.

    Recruitment End Date

  • Observational Study
    Online

    What is this Study about?

    CAN-PROTECT is a Canada-wide online study recruiting participants and caregivers of persons with dementia to explore how lifestyle, background, and caretaking factors affect our health, quality of life, cognition, behaviour, and function as we age. CAN-PROTECT data will be analyzed and jointly published by the University of Calgary in partnership with the University of Exeter.

    Eligibility Criteria

    - Age 18 years or older

    - Reside in Canada

    - Have access to a computer/touchscreen device

    - Can provide informed consent

    - Do not have a diagnosis of dementia

    - Additionally, we are enrolling participants who have previously or currently care for persons with dementia for caregiver-specific assessments

    - Ability to speak English

    Recruitment End Date