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  • Observational Study
    Online

    Medical Assistance in Dying: Descriptions of and experiences with models across Canada

    What is this Study about?

    This review examines the implementation of Medical Assistance in Dying (MAiD) across Canada. It explores the perspectives of patients, families, and friends involved in the MAiD process, capturing the human dimensions of end-of-life care. Emphasis is placed on understanding the impact of different MAiD delivery models utilized across jurisdictions. By analyzing these lived experiences, the review aims to identify strengths, challenges, and areas for improvement in MAiD service delivery across different jurisdictions. Insights from this project will inform policy, enhance equity in access, and support compassionate, paerson-centered care for all Canadians navigating the MAiD process.

    Eligibility Criteria

    You are eligible to participate if you are 18 years or older, able to communicate in English or French, and are either a patient who has inquired about MAiD services or been approved to undergo MAiD, or a family member or caregiver of a patient who has received MAiD.

    Recruitment End Date

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  • Observational Study
    Online & In-Person

    Research Study on Information Accessibility for Individuals with Dementia

    What is this Study about?

    Seeking individuals with mild, early-stage dementia ages 65+ to explore how they access daily information like weather forecasts and newspapers. The study aims to improve information accessibility for the dementia community. Participation involves a 60-90 minute session (in-person or via Zoom with caregiver) observing information access behaviors. Findings will guide strategies for making information more comprehensible and accessible. Participants will receive $50 for their time. This study is approved by York University’s ethics committee (#2024-176). For details, contact Dr. Somang Nam at [email protected].

    Eligibility Criteria

    Individuals diagnosed with mild, early-stage dementia.
    Caregivers may participate to support individuals meeting the above criteria.
    Participants must be able to engage in a 60-90 minute session, either in person or via Zoom.

    Recruitment End Date

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  • Observational Study
    Online & In-Person

    Sensory Processing in Aging and Neurodegenerative Disease

    What is this Study about?

    We are interested in how the brain changes in aging and with dementia. With this study, we will investigate how the brain senses and interprets sights and sounds. We are particularly interested in how listening to music, especially familiar music, evokes emotions and activates vivid memories. Learning how the brain processes music will help us understand why music therapy is such an effective tool for those with Alzheimer’s. We also aim to understand how the brain combines sights and sounds. This is an important part of how we navigate complex everyday situations, such as walking down a busy street. Alzheimer’s disease interferes with the brain’s ability to combine information from different senses, which could cause challenges in daily living.

    Eligibility Criteria

    You are eligible to participate in this study if you are:

    • A healthy young adult aged 18-35, a healthy older adult aged 65 and up, or an older adult with mild/early-stage dementia as diagnosed by your doctor
    • Able to provide written, informed consent to participate
    • Have normal or corrected-to-normal hearing in both ears and vision in both eyes
    • You must have no history of cerebro-vascular injury or accident (such as a stroke)
    • For adults without dementia, you must have no known neurological conditions and must not be taking any neuroactive drugs

    You will not be eligible to participate in the study if you:

    • Have metallic objects that cannot be removed for the MEG recording (such as permanent piercings and medical implants that are made from magnetic metals)
    • Are pregnant
    • Feel you cannot perform the audio-visual and/or music listening tasks

    Recruitment End Date

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  • Clinical Trial
    In-Person

    Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease (TargetTau-1)

    What is this Study about?

    The purpose of this study is to assess the effectiveness, safety, and tolerability of BMS-986446 an Anti-MTBR Tau Monoclonal Antibody in participants with Early Alzheimer's Disease.

    Eligibility Criteria

    Male or female participants aged 50 to 80 years of age
    MCI or Mild AD at Screening
    Must have a study partner

    Recruitment End Date

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  • Clinical Trial
    In-Person

    Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants with Early Alzheimer's Disease (Polaris-AD)

    What is this Study about?

    This AR1001-ADP3-US01 protocol is a double-blind, randomized, placebo-controlled, multi- center, parallel-group comparison pivotal Phase 3 study to evaluate the efficacy and safety of AR1001 for the treatment of participants with early AD.

    Eligibility Criteria

    Male or female participants aged 55 to 90 years of age
    MCI or Mild AD at Screening
    Must have a study partner

    Recruitment End Date

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  • Observational Study
    Online & In-Person

    Bridge2AI-Voice as a Biomarker of Health

    What is this Study about?

    The aim of this study is to develop a large, ethically sourced, and diverse database of voice recordings to determine whether voice has biomarkers for particular disease categories, including neurological and neurodegenerative conditions. The data that is collected will be used to develop a full open-access database to fuel artificial intelligence research related to voice.

    Eligibility Criteria

    - Are between the ages of 44-85

    - Are able to read, write, speak, and understand English

    - Are diagnosed with one of the following conditions:

    • Alzheimer's disease
    • Parkinson's disease
    • Amyotrophic Lateral Sclerosis
    • Mild Cognitive Impairment, or other types of dementia

    - Consent to provide a voice/speech sample

    Recruitment End Date

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  • Observational Study
    In-Person

    Understanding Task Sequencing in People with Mild Cognitive Impairment (MCI) and Dementia

    What is this Study about?

    This study examines how people with dementia or MCI perform household tasks, focusing on when they seek support, and which prompts help them complete tasks. The findings will help develop technologies to assist them in completing tasks more independently and safely.

    Eligibility Criteria

    You are eligible to participate if you are:

    • An older adult aged 60-85

    • Fluent in English

    • Diagnosed with dementia or MCI

    • Enrolled in outpatient care

    Recruitment End Date

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  • Clinical Trial
    In-Person

    The impact of melatonin on sleep and sleep dependent memory consolidation

    What is this Study about?

    The uOttawa Sleep Laboratory is looking for adults to participate in a research study investigating the relationship between sleep and memory. Brain activity will be recorded using functional electroencephalography (EEG).

    Eligibility Criteria

    To be included participants must be:

    - Right-handed

    - Native English speakers

    - No psychiatric disorders (past or present)

    - Healthy adults, or those with memory complaints, or those with mild cognitive impairment

    Recruitment End Date

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  • Observational Study
    In-Person

    Resting-state measures of language experience and cognitive reserve in aging and cognitive impairment

    What is this Study about?

    This study will uncover how bilingualism supports healthy cognitive aging by examining the influence of different language experiences on the timing and location of brain network activity. We will examine the timing of brain activity using electroencephalography (EEG; i.e., recordings of electrical brain activity) and the location of brain activity using magnetic resonance imaging (MRI; i.e., images of activity in different parts of the brain). Different language experience factors will additionally be explored. By measuring multiple factors (e.g., the age of second language learning, language proficiency) the effect(s) of different language experiences on the brain and cognition will become clearer.

    Eligibility Criteria

    You are eligible to participate if you:

    - are a French-English bilingual over the age of 65

    - have mild cognitive impairment

    - have Alzheimer's disease

    - are a healthy older adult (i.e., have no cognitive conditions)

     

    Please note that you do not need to be completely fluent in both English and French, just to have some familiarity, experience or training with both languages to be eligible to participate.

    Thank you for your consideration!

    Recruitment End Date

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