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  • Clinical Trial
    Online

    What is this Study about?

    ‘Bootle Blast’ combines therapy and video games. It has been used with children and youth with musculoskeletal disabilities in clinics and homes. Preliminary research supports Bootle Blast’s ability to engage players and support physical outcomes. Informal testing suggests it may also appeal to older adults. This study will test Bootle Blast’s feasibility with people with dementia. Pairs of people with dementia and their caregivers (n=10) will play Bootle Blast at home for 2 weeks. Data will include video recordings, surveys, balance tests, safety and adherence tracking, and interviews. This study aims to inform a more accessible version of Bootle Blast.

    Eligibility Criteria

    People with Dementia
    • Live in Ontario, Canada (within a two-hour drive from Toronto, Ontario)
    • Speak and understand English
    • Agree to be video and audio recorded as part of the study
    • Be able to stand and walk, with or without an assistive device (e.g., a walker)
    • Have the capacity to provide independent, informed consent


    Caregivers
    • Live in Ontario, Canada (within a two-hour drive from Toronto, Ontario)
    • Speak and understand English
    • Agree to be video and audio recorded as part of the study

    Recruitment End Date

  • Observational Study
    Online

    What is this Study about?

    By understanding the perspectives of various stakeholders involved in dementia care within Ontario health teams, we aim to enhance the quality of life for individuals living with dementia in Ontario.

    Eligibility Criteria

    You are eligible to participate if you or your loved one is living with dementia and would like to share your experience so that we can act to improve the quality of care for individuals living with dementia in Ontario.

    Recruitment End Date

  • Observational Study
    Online

    What is this Study about?

    This study looks at how an at-home nature-based virtual reality (VR) program may help people living with Alzheimer’s disease manage behavioural and psychological symptoms of dementia (BPSD), such as depression. Caregivers/study partners will have the option of taking part in the study and providing feedback regarding the VR intervention. This project will explore how VR can be used as a non-pharmacological approach to prolong aging in place for individuals with BPSD, as BPSD contributes to rates of institutionalization. This will take place completely remotely, in your own home.

    Eligibility Criteria

    AD-D Participant Inclusion Criteria: 

    1) Clinical diagnosis of mild to early-moderate stage AD (including mixed dementia with AD) using the Diagnostic and Statistical Manual of Mental Disorders, 5th Ed. Criteria (29) 

    2) Age of 50 years or older 

    3) Medical stability to participate in the trial 

    4) Patient Health Questionnaire score 5-14 

    5) Investigator judgement on whether the participant is comfortable with technology 

    6) Access to WiFi and a smart device for connecting on WebEx and downloading the Fitbit and Muse applications 

    7) Have someone available to be present during all sessions


    Caregiver Inclusion Criteria: 

    1) 18 years of age or older 

    2) Available to be present for all sessions 

    3) Ability to provide consent 

    4) Access to a smart device 

     

    Caregiver Exclusion Criteria: 

    1) Under 18 years of age

    Recruitment End Date

  • Observational Study
    Online & In-Person

    What is this Study about?

    Seeking individuals with mild, early-stage dementia ages 65+ to explore how they access daily information like weather forecasts and newspapers. The study aims to improve information accessibility for the dementia community. Participation involves a 60-90 minute session (in-person or via Zoom with caregiver) observing information access behaviors. Findings will guide strategies for making information more comprehensible and accessible. Participants will receive $50 for their time. This study is approved by York University’s ethics committee (#2024-176). For details, contact Dr. Somang Nam at [email protected].

    Eligibility Criteria

    Individuals diagnosed with mild, early-stage dementia.
    Caregivers may participate to support individuals meeting the above criteria.
    Participants must be able to engage in a 60-90 minute session, either in person or via Zoom.

    Recruitment End Date

  • Observational Study
    Online & In-Person

    What is this Study about?

    We are interested in how the brain changes in aging and with dementia. With this study, we will investigate how the brain senses and interprets sights and sounds. We are particularly interested in how listening to music, especially familiar music, evokes emotions and activates vivid memories. Learning how the brain processes music will help us understand why music therapy is such an effective tool for those with Alzheimer’s. We also aim to understand how the brain combines sights and sounds. This is an important part of how we navigate complex everyday situations, such as walking down a busy street. Alzheimer’s disease interferes with the brain’s ability to combine information from different senses, which could cause challenges in daily living.

    Eligibility Criteria

    You are eligible to participate in this study if you are:

    • A healthy young adult aged 18-35, a healthy older adult aged 65 and up, or an older adult with mild/early-stage dementia as diagnosed by your doctor
    • Able to provide written, informed consent to participate
    • Have normal or corrected-to-normal hearing in both ears and vision in both eyes
    • You must have no history of cerebro-vascular injury or accident (such as a stroke)
    • For adults without dementia, you must have no known neurological conditions and must not be taking any neuroactive drugs

    You will not be eligible to participate in the study if you:

    • Have metallic objects that cannot be removed for the MEG recording (such as permanent piercings and medical implants that are made from magnetic metals)
    • Are pregnant
    • Feel you cannot perform the audio-visual and/or music listening tasks

    Recruitment End Date

  • Clinical Trial
    Online

    What is this Study about?

    The Communication Bridge 3 Study is focused on helping adults with mild to moderate Primary Progressive Aphasia (PPA), a condition that affects language abilities due to neurodegenerative diseases. The study aims to improve functional communication and life participation by providing structured language and communication support remotely through video conferencing.

    Participants work with speech-language pathologists to practice communication techniques and learn strategies to address daily communication challenges. The study involves a series of therapy sessions, assessments, and follow-up evaluations to measure changes in communication and participation over time. By tracking participants' progress, the study hopes to identify effective approaches for enhancing quality of life for those living with PPA and their care partners.

    Eligibility Criteria

    You are eligible to participate if you speak English as a primary language, a confirmed diagnosis of PPA in mild to moderate impairment stage, a communication partner that is willing to participate, and sufficient internet connection.

    Recruitment End Date

  • Clinical Trial
    In-Person

    What is this Study about?

    The purpose of this study is to assess the effectiveness, safety, and tolerability of BMS-986446 an Anti-MTBR Tau Monoclonal Antibody in participants with Early Alzheimer's Disease.

    Eligibility Criteria

    Male or female participants aged 50 to 80 years of age
    MCI or Mild AD at Screening
    Must have a study partner

    Recruitment End Date

  • Clinical Trial
    In-Person

    What is this Study about?

    This AR1001-ADP3-US01 protocol is a double-blind, randomized, placebo-controlled, multi- center, parallel-group comparison pivotal Phase 3 study to evaluate the efficacy and safety of AR1001 for the treatment of participants with early AD.

    Eligibility Criteria

    Male or female participants aged 55 to 90 years of age
    MCI or Mild AD at Screening
    Must have a study partner

    Recruitment End Date

  • Observational Study
    In-Person

    What is this Study about?

    This study examines how people with dementia or MCI perform household tasks, focusing on when they seek support, and which prompts help them complete tasks. The findings will help develop technologies to assist them in completing tasks more independently and safely.

    Eligibility Criteria

    You are eligible to participate if you are:

    • An older adult aged 60-85

    • Fluent in English

    • Diagnosed with dementia or MCI

    • Enrolled in outpatient care

    Recruitment End Date