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  • Observational Study
    Online

    What is this Study about?

    This review examines the implementation of Medical Assistance in Dying (MAiD) across Canada. It explores the perspectives of patients, families, and friends involved in the MAiD process, capturing the human dimensions of end-of-life care. Emphasis is placed on understanding the impact of different MAiD delivery models utilized across jurisdictions. By analyzing these lived experiences, the review aims to identify strengths, challenges, and areas for improvement in MAiD service delivery across different jurisdictions. Insights from this project will inform policy, enhance equity in access, and support compassionate, paerson-centered care for all Canadians navigating the MAiD process.

    Eligibility Criteria

    You are eligible to participate if you are 18 years or older, able to communicate in English or French, and are either a patient who has inquired about MAiD services or been approved to undergo MAiD, or a family member or caregiver of a patient who has received MAiD.

    Recruitment End Date

  • Observational Study
    Online

    What is this Study about?

    This study looks at how an at-home nature-based virtual reality (VR) program may help people living with Alzheimer’s disease manage behavioural and psychological symptoms of dementia (BPSD), such as depression. Caregivers/study partners will have the option of taking part in the study and providing feedback regarding the VR intervention. This project will explore how VR can be used as a non-pharmacological approach to prolong aging in place for individuals with BPSD, as BPSD contributes to rates of institutionalization. This will take place completely remotely, in your own home.

    Eligibility Criteria

    AD-D Participant Inclusion Criteria: 

    1) Clinical diagnosis of mild to early-moderate stage AD (including mixed dementia with AD) using the Diagnostic and Statistical Manual of Mental Disorders, 5th Ed. Criteria (29) 

    2) Age of 50 years or older 

    3) Medical stability to participate in the trial 

    4) Patient Health Questionnaire score 5-14 

    5) Investigator judgement on whether the participant is comfortable with technology 

    6) Access to WiFi and a smart device for connecting on WebEx and downloading the Fitbit and Muse applications 

    7) Have someone available to be present during all sessions


    Caregiver Inclusion Criteria: 

    1) 18 years of age or older 

    2) Available to be present for all sessions 

    3) Ability to provide consent 

    4) Access to a smart device 

     

    Caregiver Exclusion Criteria: 

    1) Under 18 years of age

    Recruitment End Date

  • Observational Study
    Online & In-Person

    What is this Study about?

    Seeking individuals with mild, early-stage dementia ages 65+ to explore how they access daily information like weather forecasts and newspapers. The study aims to improve information accessibility for the dementia community. Participation involves a 60-90 minute session (in-person or via Zoom with caregiver) observing information access behaviors. Findings will guide strategies for making information more comprehensible and accessible. Participants will receive $50 for their time. This study is approved by York University’s ethics committee (#2024-176). For details, contact Dr. Somang Nam at [email protected].

    Eligibility Criteria

    Individuals diagnosed with mild, early-stage dementia.
    Caregivers may participate to support individuals meeting the above criteria.
    Participants must be able to engage in a 60-90 minute session, either in person or via Zoom.

    Recruitment End Date

  • Observational Study
    Online & In-Person

    What is this Study about?

    We are interested in how the brain changes in aging and with dementia. With this study, we will investigate how the brain senses and interprets sights and sounds. We are particularly interested in how listening to music, especially familiar music, evokes emotions and activates vivid memories. Learning how the brain processes music will help us understand why music therapy is such an effective tool for those with Alzheimer’s. We also aim to understand how the brain combines sights and sounds. This is an important part of how we navigate complex everyday situations, such as walking down a busy street. Alzheimer’s disease interferes with the brain’s ability to combine information from different senses, which could cause challenges in daily living.

    Eligibility Criteria

    You are eligible to participate in this study if you are:

    • A healthy young adult aged 18-35, a healthy older adult aged 65 and up, or an older adult with mild/early-stage dementia as diagnosed by your doctor
    • Able to provide written, informed consent to participate
    • Have normal or corrected-to-normal hearing in both ears and vision in both eyes
    • You must have no history of cerebro-vascular injury or accident (such as a stroke)
    • For adults without dementia, you must have no known neurological conditions and must not be taking any neuroactive drugs

    You will not be eligible to participate in the study if you:

    • Have metallic objects that cannot be removed for the MEG recording (such as permanent piercings and medical implants that are made from magnetic metals)
    • Are pregnant
    • Feel you cannot perform the audio-visual and/or music listening tasks

    Recruitment End Date

  • Observational Study
    Online & In-Person

    What is this Study about?

    The aim of this study is to develop a large, ethically sourced, and diverse database of voice recordings to determine whether voice has biomarkers for particular disease categories, including neurological and neurodegenerative conditions. The data that is collected will be used to develop a full open-access database to fuel artificial intelligence research related to voice.

    Eligibility Criteria

    - Are between the ages of 44-85

    - Are able to read, write, speak, and understand English

    - Are diagnosed with one of the following conditions:

    • Alzheimer's disease
    • Parkinson's disease
    • Amyotrophic Lateral Sclerosis
    • Mild Cognitive Impairment, or other types of dementia

    - Consent to provide a voice/speech sample

    Recruitment End Date

  • Observational Study
    In-Person

    What is this Study about?

    This study examines how people with dementia or MCI perform household tasks, focusing on when they seek support, and which prompts help them complete tasks. The findings will help develop technologies to assist them in completing tasks more independently and safely.

    Eligibility Criteria

    You are eligible to participate if you are:

    • An older adult aged 60-85

    • Fluent in English

    • Diagnosed with dementia or MCI

    • Enrolled in outpatient care

    Recruitment End Date

  • Clinical Trial
    Ontario

    What is this Study about?

    McMaster University, in partnership with Ressam Gardens Memory Care Community, is conducting a study on the effects of brain stimulation in individuals aged 50 and older with dementia or memory loss. The research focuses on using repetitive transcranial magnetic stimulation (rTMS), a non-invasive technique that delivers magnetic pulses to the brain, to enhance cognitive function and balance. The goal is to extend the positive effects of brain stimulation in improving cognition and balance in individuals with dementia.

    Eligibility Criteria

    You are eligible to participate if you…

    1.) Diagnosed with Dementia and/or memory loss by a clinician

    2.) Exhibit adequate oral communication skills and cognitive function sufficient to obtain a score ranging between 10-27 on the Mini-Mental State Exam

    3.) Walk or stand with or without personnel or assistive devices

    4.) Individuals must be greater than or equal to 50 years of age

    Recruitment End Date

  • Observational Study
    Online

    What is this Study about?

    This study aims to explore how the website, the Driving and Dementia Roadmap (DDR), is experienced by and impacts how people with dementia and family/friend carers manage the driving cessation process. Participants will be asked to use the DDR for 2-6 weeks, record their thoughts in a diary and take part in an interview or focus group.

    Eligibility Criteria

    - Are a person living with dementia who is still driving or has stopped driving within the past 2 years

    - Are family member or friend who is caring for or providing support to a person with dementia who is still driving or has stopped driving within the past two years

    - Are a healthcare provider who cares for people living with dementia

    - Ability to speak English

    Recruitment End Date

  • Observational Study
    In-Person

    What is this Study about?

    Our study titled "Investigating the Role of Quantitative Susceptibility Mapping and Oxygen Extraction Fraction as Advanced Neuroimaging Biomarkers in Alzheimer's Disease" aims to develop non-invasive diagnostic biomarkers for Alzheimer's Disease (AD). We focus on evaluating the potential of QSM and OEF to differentiate between AD, Mild Cognitive Impairment (MCI), and Cognitively Unimpaired populations and to predict amyloid and tau pathology, using a Systems Biology approach. Leveraging the McGill University's TRIAD cohort, the study utilizes advanced imaging and machine learning to predict amyloid and tau presence, which could transform AD diagnostics and treatment. Methodologically, it involves preprocessing neuroimaging data and employing machine learning classifiers to analyze these features. The anticipated outcomes include validating QSM and OEF as non-invasive biomarkers for AD, establishing their correlation with amyloid and tau proteins, and developing predictive models for clinical decision-making, potentially resulting in significant advancements in AD diagnostics.

    Eligibility Criteria

    Are a member of the TRIAD cohort at McGill University, falling within one of the following categories: young control, cognitively unimpaired, mild cognitive impairment, or Alzheimer's Disease.

    Are willing and able to undergo advanced neuroimaging techniques including MRI and PET without contraindications.

    Have not had any significant neurological conditions (other than AD for the AD group) that might interfere with the results of the study.

    Have no metal implants, devices, or other conditions that may contraindicate or distort MRI imaging.

    Are not currently participating in other clinical trials or studies that involve interventions which might interfere with the results of this study.

    Are able and willing to provide informed consent for participation in the study or have a legally authorized representative who can do so.

    Do not have a history of substance abuse or other conditions that might confound the imaging and cognitive data.

    Have not undergone any significant head trauma or surgery in the past 6 months.

    Are not pregnant or planning to become pregnant during the duration of the study.

    Are willing to comply with all study-related procedures, imaging sessions, and follow-up evaluations.

    Ability to speak English and French

    Recruitment End Date